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eCAM 2009 6(Supplement 1):81-86; doi:10.1093/ecam/nep098
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Taeyeumjoweetang Affects Body Weight and Obesity-related Genes in Mice

Si-Woo Lee1, Jong-Hyang Yoo1, Su-Kyung Lee2, Kyung-Soo Keum3, Do-Gon Ryu4 and Kang-Beom Kwon4

1Korea Institute of Oriental Medicine, Daejeon, South Korea, 2Department of Rehabilitation, 3Department of Classics and 4Department of Physiology, College of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea

Taeyeumjoweetang (TYJWT) is a herbal medication that was mentioned in Jema Lee's Donguisusebowon, which is a book about Sasang constitutional medicine. Tae-eumnis, one of the four constitutions, tend to suffer from metabolic diseases such as obesity and diabetes. It is widely used to treat the digestive problems and obesity of Tae-eumins. We divided mice that were fed a normal diet for 48 days into control, TYJWT 250 mg kg–1 and TYJWT 500 mg kg–1 groups. After carrying out the experiments, the serum levels of leptin, adiponectin, ghrelin and resistin were measured. The results showed that TYJWT significantly reduced the weights of mice that were fed a normal diet, and that this was due to a decrease in food intake. Also, the two TYJWT groups had lower serum levels of leptin compared to the control group, and the ghrelin levels were proportionately increased by the dosage of TYJWT given. These results show that TYJWT has obesity-suppressing effects similar to those previously reported using high fat diets. In addition, these results also provide evidence that TYJWT has anti-obesity effects.

Keywords: ghrelin – leptin – Sasang constitutional medicine

For reprints and all correspondence: Prof. Kang-Beom Kwon, Department of Physiology, College of Oriental Medicine, Wonkwang University, 344-2 Shinyoung-dong, Iksan, Chonbuk 570-749, Republic of Korea. Tel: +82-63-850-6917; Fax: +82-63-842-3138; E-mail: desson{at}wonkwang.ac.kr

Received March 16, 2009; accepted July 9, 2009


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