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eCAM Advance Access originally published online on October 4, 2007
eCAM 2009 6(3):375-378; doi:10.1093/ecam/nem101
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Hangekobokuto (Banxia-houpo-tang), a Kampo Medicine that Treats Functional Dyspepsia

Tetsuro Oikawa1, Go Ito1, Takayuki Hoshino1,2, Hidehiko Koyama3 and Toshihiko Hanawa1,2

1Oriental Medicine Research Center of the Kitasato Institute, Tokyo, 2Graduate School of Medical Science, Kitasato University, Kanagawa and 3Department of Internal Medicine, International University of Health and Welfare Mita Hospital, Japan

Although abdominal bloating is one of the most bothersome symptoms experienced by patients with functional dyspepsia (FD), therapeutic drugs to relieve abdominal bloating have not been established. We investigated the Kampo (Chinese herbal) medicine, Hangekobokuto (Banxia-houpo-tang, HKT) for patients with FD from the standpoint of bowel gas retention. The bowel gas volume calculated from a plain abdominal radiogram (gas volume score, GVS) in FD patients was significantly higher than that in healthy subjects. Two week administration of HKT in the FD patients showed a significant decrease of GVS. Furthermore, gastrointestinal symptoms, especially symptoms of abdominal pain, indigestion and constipation, all of which are closely related to abdominal bloating, improved significantly in FD patients after the administration of HKT. These results suggest that HKT improves abdominal bloating accompanied by the reduction of bowel gas in FD patients.

Keywords: abdominal bloating – aerophagia – functional dyspepsia – functional gastrointestinal disorders – herbal medicine – prokinetics

For reprints and all correspondence: Tetsuro Oikawa, Oriental Medicine Research Center of the Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan. Tel: 03-3444-6161(ext. 4667); Fax: 03-3445-8448; E-mail: oikawa-t{at}kitasato.or.jp

Received November 21, 2006; accepted June 19, 2007


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