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eCAM Advance Access originally published online on September 26, 2007
eCAM 2009 6(2):239-245; doi:10.1093/ecam/nem100
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pain Controlling and Cytokine-regulating Effects of Lyprinol, a Lipid Extract of Perna Canaliculus, in a Rat Adjuvant-induced Arthritis Model

Chi-Ho Lee1, John Hon-Kei Lum1, Curtise Kin-Cheung Ng2, Janice McKay2, Yoki Kwok-Chu Butt1, Man-Sau Wong1 and Samuel Chun-Lap Lo1

1State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen and Department of Applied Biology and Chemical Technology and 2Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China

Using an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract of Perna canaliculus (Lyprinol®) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol® to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol® after day 9–14. The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol® decreased the levels of the pro-inflammatory cytokines TNF-{alpha} and IFN-{gamma}, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol® were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract of P. canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.

Keywords: adjuvant-induced arthritis – inflammatory cytokines – Lyprinol® – NZGLM, pain score

For reprints and all correspondence: Prof. Samuel C. L. Lo, Dept. of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China. Tel: +(852) 34008669; Fax: +(852) 23649932; E-mail: bcsamlo{at}inet.polyu.edu.hk

Received November 9, 2006; accepted July 10, 2007


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