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eCAM Advance Access originally published online on June 11, 2007
eCAM 2009 6(1):91-98; doi:10.1093/ecam/nem061
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Regulation of Cellular Metabolism and Cytokines by the Medicinal Herb Feverfew in the Human Monocytic THP-1 Cells

Chin-Fu Chen and Chun-Huai Cheng

Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA

The herb feverfew is a folk remedy for various symptoms including inflammation. Inflammation has recently been implicated in the genesis of many diseases including cancers, atherosclerosis and rheumatoid arthritis. The mechanisms of action of feverfew in the human body are largely unknown. To determine the cellular targets of feverfew extracts, we have utilized oligo microarrays to study the gene expression profiles elicited by feverfew extracts in human monocytic THP-1 cells. We have identified 400 genes that are consistently regulated by feverfew extracts. Most of the genes are involved in cellular metabolism. However, the genes undergoing the highest degree of change by feverfew treatment are involved in other pathways including chemokine function, water homeostasis and heme-mediated signaling. Our results also suggest that feverfew extracts effectively reduce Lipopolysaccharides (LPS)-mediated TNF-{alpha} and CCL2 (MCP-1) releases by THP-1 cells. We hypothesize that feverfew components mediate metabolism, cell migration and cytokine production in human monocytes/macrophages.

Keywords: feverfew – herbal medicine – immune response – microarray – monocyte

For reprints and all correspondence: Chin-Fu Chen, Department of Genetics and Biochemistry, 100 Jordan Hall, Clemson University, Clemson, SC 29634, USA. Tel: +1-864-656-0748; Fax: +1-864-656-4273; E-mail: cchen{at}clemson.edu

Received October 30, 2006; accepted April 11, 2007


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