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eCAM Advance Access originally published online on March 12, 2007
eCAM 2008 5(2):199-203; doi:10.1093/ecam/nem008
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Clinical Evaluation of Perspiration Reducing Effects of a Kampo Formula, Shigyaku-san, on Palmoplantar Hidrosis

Fumino Ninomiya

Aoki Clinic 4–17, Chuocho, Atami, Shizuoka, 4130015, Japan

Palmoplantar hidrosis is common in patients who are susceptible to strains on the autonomic nervous system, and stress and mental strain have been proven to produce sweating in this population. Shigyaku-san (Sini san, TJ-35: Tsumura & Co.) is effective for relieving stagnation of ‘liver Qi and vital energy’ in traditional Chinese medicine theory; this brings about improvement of palmoplantar hidrosis. The effect of Shigyaku-san on 40 patients was evaluated based on changes in palmoplantar sweat volume and skin temperature before and after stress loading. We also measured changes in the palmoplantar sweat volume and skin temperature due to stress load in 35 healthy controls who did not receive Shigyaku-san. Before treatment, the pre-stress sweat volume in patients was larger than that in healthy controls, however, after Shigyaku-san treatment, their pre-stress sweat volume decreased. With stress, the sweat volume increased in both patients and controls, but the net increase in the patients was larger than that in healthy controls. After Shigyaku-san treatment, the net increase of sweat volume due to stress was smaller than that of pretreatment, however, it did not show a significant difference with that of healthy controls. The palmoplantar skin temperature of the patients before treatment was lower than that of healthy controls. Palmoplantar skin temperature rose with stress loading in healthy controls, but decreased in pretreatment patients. Shigyaku-san treatment reduced the palmoplantar perspiration in palmoplantar hidrosis patients at rest and under stress. Furthermore, it also improved other serious complications, especially coldness of the extremities.

Keywords: Kampo – palmoplantar hyperhidrosis – Shigyaku-san (sini san)

For reprints and all Correspondence: Fumino Ninomiya, Tel: +81-557-81-7285; Fax: +81-557-81-1655; E-mail: hijikata{at}hcn.zaq.ne.jp

Received December 27, 2005; accepted January 16, 2007


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