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eCAM Advance Access originally published online on March 15, 2007
eCAM 2008 5(2):187-190; doi:10.1093/ecam/nem019
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Investigation of Indian Diospyros Species for Antiplasmodial Properties

V. S. Satyanarayana Kantamreddi and Colin W. Wright

The School of Pharmacy, University of Bradford, West Yorkshire, BD7 1DP, UK

Despite decades of intense research, malaria remains a deadly disease worldwide and new antimalarials are urgently needed due to increasing drug resistance of Plasmodium falciparum to existing drugs. This article reports the evaluation of four Indian Diospyros species viz., Diospyros melanoxylon, D. peregrina, D. sylvatica, D. tomentosa for antiplasmodial activities against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of P. falciparum. Six of eight methanolic extracts were found to have significant activity, (IC50 = 16.5–92.9 µg ml–1), against strain 3D7 and five of these showed similar activities against strain K1 (IC50 = 20.5–121.6 µg ml–1). Diospyros sylvatica was found to be the most active species (IC50 = 16.5–29.4 µg ml–1) and is worthy of further investigation.

Keywords: Diospyros melanoxylon – Diospyros peregrina – Diospyros sylvatica – Diospyros tomentosa – Ebenaceae – Malaria – Plasmodium falciparum

For reprints and all correspondence: V. S. Satyanarayana Kantamreddi, University of Bradford, Bradford West Yorkshire BD7 1DP, UK. Tel: +44 0 1274 234745; Fax: +44 0 1274 234660; E-mail: v.s.s.kantamreddi{at}bradford.ac.uk; vssn_k{at}yahoo.com

Received August 16, 2006; accepted January 16, 2007


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