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eCAM Advance Access originally published online on March 3, 2007
eCAM 2008 5(1):91-94; doi:10.1093/ecam/nem003
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Post-Coital Antifertility Activity of Hibiscus rosa-sinensis Linn. roots

Neeru Vasudeva and S. K. Sharma

Pharmacognosy and Phytochemistry Division, Faculty of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India

Ancient literature mentions the use of a number of plants/preparations for fertility regulation. Some local contraceptive agents have also been described in Ayurvedic and Unani texts. Documented experiments or clinical data are, however, lacking. Therefore, the present study was undertaken to explore the antifertility and estrogenic activity of ethanolic extract of the roots of Hibiscus rosa-sinensis Linn. A strong anti-implantation (inhibition 100%) and uterotropic activity was observed at the dose level of 400 mg/kg body weight. Histological studies were carried out to confirm this effect.

Keywords: anti-implantation – estrogenic – Hibiscus rosa-sinensis – uterotropic

For reprints and all correspondence: S. K. Sharma, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India. Fax: -01662-276240; E-mail: drsks_gjuhsr{at}yahoo.co.in

Received April 29, 2006; accepted January 11, 2007


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