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eCAM Advance Access originally published online on October 27, 2006
eCAM 2007 4(3):361-366; doi:10.1093/ecam/nel070
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Administration of Ratanhia-based herbal oral care products for the prophylaxis of oral mucositis in cancer chemotherapy patients: a clinical trial

Patric Tiemann1, Michael Toelg2 and Mac H. Ramos F.3

1Spreestrasse 3, 64295 Darmstadt Germany, 2Mediveritas, Zweibrückenstrasse 15 D-80331 München, Germany and 3Weleda AG, Dychweg 14 CH-4144 Arlesheim, Switzerland

Oral complications are a common side effect of cancer chemotherapy, as antineoplastic agents affect both the immune system and the oral mucosa. This study demonstrates preventive and therapeutic effects of dental treatment and regular use of Weleda Ratanhia-Mundwasser® (herbal mouthwash) and Weleda Pflanzen-Zahngel® (herbal toothgel) on oral mucositis during chemotherapy. Thirty-two female patients with breast cancer starting on chemotherapy were evaluated in this study. Plaque index, gingival index, degree of mucositis and 10 single symptoms were monitored once weekly for four consecutive weeks. After four weeks, plaque and gingival indexes were slightly decreased compared to baseline values. The degree of mucositis was increased by one grade in 15.6 % of the patients and over 70 % remained without symptoms. On the whole, single symptoms decreased from day 7 since beginning of chemotherapy to day 28. Mucositis symptoms were moderate in severity, and the results indicate a positive influence of using Weleda Ratanhia-Mundwasser and Weleda Pflanzen-Zahngel. Further studies might be promising.

Keywords: oral mucositis – chemotherapy (side effects) – oral hygiene – herbal preparations – ratanhia

For reprints and all correspondence: Dr Mac H. Ramos F., Weleda AG, Dychweg 14, CH-4144 Arlesheim, Switzerland. Tel: +41-(0) 61-7052121; Fax: +41-(0) 61-7052121; E-mail: mramos{at}weleda.ch

Received October 20, 2005; accepted September 14, 2006


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