Skip Navigation


eCAM Advance Access originally published online on December 12, 2006
eCAM 2007 4(3):355-359; doi:10.1093/ecam/nel102
This Article
Right arrow Full Text Freely available
Right arrow Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
4/3/355    most recent
nel102v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Vieira, J. R. C.
Right arrow Articles by Leite, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vieira, J. R. C.
Right arrow Articles by Leite, S. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Indigofera suffruticosa: An Alternative Anticancer Therapy

Jeymesson Raphael Cardoso Vieira1, Ivone Antônia de Souza2, Silene Carneiro do Nascimento2 and Sônia Pereira Leite3

1Universidade Federal de Pernambuco/Departamento de Patologia do Centro de Ciências da Saúde Recife-PE Recife-PE, Brazil, 2Universidade Federal de Pernambuco/Departamento de Antibióticos do Centro de Ciências Biológicas Recife-PE, Brazil and 3Universidade Federal de Pernambuco/Departamento de Histologia e Embriologia do Centro de Ciências Biológicas Recife-PE, Brazil

Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. The main aim of the present work was to investigate the cytotoxic and antitumor effects of aqueous extracts of leaves of I. suffruticosa obtained by infusion and maceration as well as to evaluate the toxicological properties. Aqueous extracts did not exhibit cytotoxicity against HEp-2 (human epidermoid cancer cell) cell lines by MTT method. From the aqueous extract by infusion, the toxicological assay showed low order of toxicity. The antitumor effect of aqueous extracts by infusion (64.53%) and maceration (62.62%) against sarcoma 180 in mice at a dose of 50 mg kg–1 (intraperitoneally), based on low order of toxicity was comparable to the control group, which showed 100% development. Considering the low order of toxicity and that it is highly effective in inhibiting growth of solid tumors, the aqueous extracts of leaves of I. suffruticosa may be used as an alternative anticancer agent.

Keywords: antitumor – aqueous extract – cytotoxicity – Indigofera suffruticosa – toxicity

For reprints and all correspondence: Sônia Pereira Leite, Laboratório de Cultura de Células II, Departamento de Histologia e Embriologia do Centro de Ciências Biológica da Universidade Federal de Pernambuco (UFPE), Cidade Universitária, Recife, 50.670-420, Pernambuco, Brazil. Tel: +55-81-21268515; Fax: +55-81-21268516; E-mail: spl{at}ufpe.br

Received July 5, 2006; accepted October 30, 2006


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
T. L. Johnson, M. B. Lai, J. C. K. Lai, and A. Bhushan
Inhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A
Evid. Based Complement. Altern. Med., February 29, 2008; (2008) nen011v1.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.