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eCAM Advance Access originally published online on December 12, 2006
eCAM 2007 4(3):351-353; doi:10.1093/ecam/nel099
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

In Vitro Anti-Candida Activity of Zataria multiflora Boiss

Ali Zarei Mahmoudabadi1, Muhammad Ali Dabbagh2 and Zahra Fouladi3

1Department of Medical Mycoparasitology, School of Medicine, Jundishapour University of Medical Sciences Ahwaz, Iran, 2School of Pharmacy, Jundishapour University of Medical Sciences Ahwaz, Iran and 3School of Nursing and Midwifery, Jundishapour University of Medical Sciences Ahwaz, Iran

Zataria multiflora Boiss known as Avishan Shirazi (in Iran) is one of the valuable Iranian medicinal plants. The aim of study was to evaluate anti-Candida activity of Z. multiflora against different species of Candida in vitro. Anti-Candida activity of the aqueous, ethanolic and methanolic maceration extract of the aerial parts of Z. multiflora Boiss was studied in vitro. Anti-Candida activity against Candida species was done using serial dilutions of extracts in Sabouraud's dextrose agar. Minimal inhibitory concentration (MIC) of the methanolic and ethanolic extracts was 70.7 and 127 mg l–1, respectively. Aqueous extract showed no remarkable activity against Candida species. We conclude that methanolic extract of the aerial parts of Z. multiflora Boiss has more anti-Candida effect at 70.7 mg l–1 compared to ethanolic extract 127 mg l–1. In addition, the isolates of Candida parapsilosis were more susceptible to methanolic extract than other tested species.

Keywords: anti-Candida – Candida – herbal medicine – Zataria multiflora Boiss

For reprints and all correspondence: Ali Zarei Mahmoudabadi, Department of Medical Mycoparasitology, School of Medicine, Jundishapour University of Medical Sciences, Ahwaz, Iran. Tel: +98611-3330074; Fax: +98611-3332036; E-mail: zarei40{at}hotmail.com

Received May 15, 2006; accepted October 30, 2006


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