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eCAM Advance Access originally published online on November 27, 2006
eCAM 2007 4(2):247-250; doi:10.1093/ecam/nel089
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

Derrick Lonsdale

24700 Center Ridge Road, Westlake, OH 44145, USA

Non-caloric nutrients (NCN) are extremely numerous and it is more than obvious that they work in a team relationship. These vitally important interactions are, for the most part, poorly understood. These brief case reports illustrate this in the therapeutic use of thiamin in a clinical setting. The initially abnormal erythrocyte transketolase activity (TKA) and/or the thiamin pyrophosphate effect (TPPE), indicating intracellular cofactor deficiency, usually improves with thiamin administration. Biochemical correction of the abnormality is, however, invariably dependent on the provision of other NCN, especially magnesium. In two patients reported here, this correction required several infusions containing magnesium and other NCN administered intravenously. In a third patient, hemoconcentration associated with an abnormal TPPE was normalized after administration of nutrients that included thiamin and magnesium.

Keywords: transketolase – thiamin/magnesium deficiency – hemoconcentration

For reprints and all correspondence: Derrick Lonsdale, 24700 Center Ridge Road, Westlake, OH 44145, USA. Tel: +1-440-835-0104; Fax: +1-440-871-1404; E-mail: dlonsdale{at}pol.net

Received March 4, 2006; accepted October 12, 2006


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