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eCAM Advance Access originally published online on November 2, 2006
eCAM 2007 4(2):195-202; doi:10.1093/ecam/nel080
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Psychological Stress-Induced Oxidative Stress as a Model of Sub-Healthy Condition and the Effect of TCM

Lei Wang1,3, Gong Muxin1,3, Hiroshi Nishida1, Chieko Shirakawa2, Shinji Sato1 and Tetsuya Konishi1

1Niigata University of Pharmacy and Applied Life Sciences Niigata 950-2081,, 2Niigata College of Medical Technology, Niigata 950-2076, Japan and 3School of Traditional Chinese Medicine, Capital Medical University Beijing, China

Distress-mediated tissue oxidative stress was examined as a model of sub-healthy condition defined in traditional Chinese medicine theory. Mice were subjected to psychologically stressful conditions by whiskers removal. Under this condition, spontaneous locomotive activity was significantly enhanced in the dark (P < 0.05 versus the control mice in three different movements), and granulocytes/lymphocytes balance shifted to granulocytes. At the same time, peroxynitrite level in blood plasma increased to ~180% from that of the control mice at 6 h after removal of the whiskers (P < 0.01), and was maintained even after 12 h. Both protein carbonyl formation and lipid peroxidation were significantly increased under this condition in brain, heart, liver and spleen at 6 h after removal of whiskers (P < 0.05 or P < 0.01), and these levels were maximized after 12 h (increased to 120–160%, P < 0.05 or P < 0.01). The oxidative tissue injuries observed at 12 h after the removal of the whiskers were effectively prevented by two traditional Chinese medicine formula: Shengmai San (SMS) and Ling Gui Zhu Gan Tang (LGZGT), when administered for 5 days before the removal of the whiskers. Therefore, this stress model is considered useful in assessing the preventive potential of antioxidants and antioxidant-based herbal mixtures in treating the pathophysiology associated with psychological or emotional distress.

Keywords: antioxidant-based herbal medicine – oxidative stress – peroxynitrite – psychological stress – sub-healthy condition – traditional Chinese medicine

For reprints and all correspondence: Tetsuya Konishi, Niigata University of Pharmacy and Applied Life Sciences, Higashi-jima 265-1, Niigata, Niigata 956-8603, Japan. Tel: +81-250-25-5127; Fax: +81-250-25-5127; E-mail: konishi{at}niigata-pharm.ac.jp

Received January 20, 2006; accepted September 25, 2006


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