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eCAM Advance Access originally published online on August 30, 2006
eCAM 2007 4(1):77-82; doi:10.1093/ecam/nel057
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Use of Magnetic Nanoparticles to Visualize Threadlike Structures Inside Lymphatic Vessels of Rats

Hyeon-Min Johng1, Jung Sun Yoo1, Tae-Jong Yoon2, Hak-Soo Shin1, Byung-Cheon Lee1,3, Changhoon Lee1, Jin-Kyu Lee2 and Kwang-Sup Soh1

1Biomedical Physics Laboratory, FPRD School of Physics and Astronomy, 2Materials Chemistry Laboratory School of Chemistry and 3Research Institute of Basic Sciences Seoul National University, Seoul, Korea

A novel application of fluorescent magnetic nanoparticles was made to visualize a new tissue which had not been detectable by using simple stereomicroscopes. This unfamiliar threadlike structure inside the lymphatic vessels of rats was demonstrated in vivo by injecting nanoparticles into lymph nodes and applying magnetic fields on the collecting lymph vessels so that the nanoparticles were taken up by the threadlike structures. Confocal laser scanning microscope images of cryosectioned specimens exhibited that the nanoparticles were absorbed more strongly by the threadlike structure than by the lymphatic vessels. Further examination using a transmission electron microscope revealed that the nanoparticles had been captured between the reticular fibers in the extracellular matrix of the threadlike structures. The emerging technology of nanoparticles not only allows the extremely elusive threadlike structures to be visualized but also is expected to provide a magnetically controllable means to investigate their physiological functions.

Keywords: acupuncture meridian – Bonghan duct – lymph – nanoparticle – transmission electron microscope

For reprints and all correspondence: Kwang-Sup Soh, Biomedical Physics Laboratory, School of Physics, Seoul National University, Seoul 151-747, Korea. Tel: +82-2-880-7750; Fax: +82-2-878-9172; E-mail: kssoh{at}phya.snu.ac.kr

Received December 16, 2005; accepted July 25, 2006


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