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eCAM Advance Access originally published online on October 27, 2006
eCAM 2006 3(4):541-545; doi:10.1093/ecam/nel073
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Improvement of Memory by Means of Ultra-Low Doses of Antibodies to S-100B Antigen

O. I. Epstein, I. F. Pavlov and M. B. Shtark

Institute of Molecular Biology and Biophysics, Siberian Department of Russian Academy of Medical Sciences Novosibirsk, Russia

Antigen S-100B of nervous tissue, according to the data of numerous studies, affects the mechanisms of nervous system plasticity and memory. The influence of ultralow doses of antibodies to S-100B (6C dilution, according to the homeopathic pharmacopoeia) has been studied on three learning behavioral models on Wistar rats, which were inhibitory avoidance, choosing of bowls with sucrose and feeding behavior cessation after auditory signal. For all three tasks, parameters of reproduction of the learned skills improved after per oral administration of potentiated antibodies to S-100B antigen immediately after learning. Possible mechanisms of the anti-S-100B antibodies influence on memory formation are discussed.

Keywords: Antigen S-100B – antibodies – ultra-low doses, memory

For reprints and all correspondence: Ilja Pavlov, Institute of Molecular Biology and Biophysics, Siberian Department of Russian Academy of Medical Sciences, 2 Novosibirsk 630117, Russia. Tel/Fax: +73-833321256; E-mail: pavlov{at}soramn.ru


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