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eCAM Advance Access originally published online on May 26, 2006
eCAM 2006 3(4):469-473; doi:10.1093/ecam/nel031
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© The Author (2006). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross-sectional Before/After Clinical Trial

Akram Ranjbar1, Sara Khorami1, Mehdi Safarabadi1, Amene Shahmoradi1, Ali Akbar Malekirad1, Katyon Vakilian1, Ali Mandegary2,3 and Mohammad Abdollahi3

1 Arak University of Medical Sciences Arak, Iran, 2 Faculty of Pharmacy, Kerman University of Medical Sciences Kerman, Iran, and 3 Faculty of Pharmacy, Pharmaceutical Sciences Research Center Tehran University of Medical Sciences, Tehran, Iran

Medicinal plants are recognized as sources of natural antioxidants that can protect from biological system oxidative stress. The present cross-sectional before/after clinical trial was carried out to investigate the antioxidant properties of the decoction of the flowers of Echium amoenum Fisch & C.A. Mey in humans. A group of 38 healthy subjects was invited to use the E. amoenum (7 mg kg–1) twice daily for 14 days. Blood samples before and after entering the study were measured for lipid peroxidation level (LPO), total antioxidant capacity (TAC) and total thiol (SH) molecules. A significant reduction of blood LPO (24.65 ± 11.3 versus 19.05 ± 9.7, P = 0.029) was observed after 14 days of E. amoenum consumption. Blood TAC (1.46 ± 0.51 versus 1.70 ± 0.36, P = 0.018) and total thiol molecules (0.49 ± 0.11 versus 0.56 ± 0.12, P = 0.001) increased after 14 days of E. amoenum consumption. In conclusion, this antioxidative stress potential of E. amoenum may be due to its bioactive antioxidant components, especially rosmarinic acid and flavonoids. In recent years the importance of oxidative stress in the pathophysiology of many human disorders has been confirmed, thus use of this plant as a dietary supplement is highly recommended.

Keywords: antioxidant – decoction – Echium amoenum Fisch & C.A. Mey – human – oxidative stress

For reprints and all correspondence: Prof. Mohammad Abdollahi, Laboratory of Toxicology, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Poursina Avenue, Tehran University, Tehran, PO Box 14155-6451, Iran. Tel/Fax: +98-21-6959104; E-mail: mohammad.abdollahi{at}utoronto.ca/ mohammad{at}tums.ac.ir


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