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eCAM Advance Access originally published online on October 27, 2006
eCAM 2006 3(4):447-457; doi:10.1093/ecam/nel075
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

DNA Microarrays in Herbal Drug Research

Preeti Chavan, Kalpana Joshi and Bhushan Patwardhan

Bioprospecting Laboratory, Interdisciplinary School of Health Sciences University of Pune, Pune 411007, India

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.

Keywords: Drug discovery – evidence-based medicine – gene expression – genotyping – pharmacodynamics – transcription profiling

For reprints and all correspondence: Dr Bhushan Patwardhan, Interdisciplinary School of Health Sciences, University of Pune, Ganeshkind, Pune 411007, India. Tel: +91-20-2591758; Fax: +91-20-2590174; E-mail: bhushan{at}unipune.ernet.in


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