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eCAM Advance Access originally published online on July 5, 2006
eCAM 2006 3(3):309-316; doi:10.1093/ecam/nel047
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Review

Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: Modulating Tumor Immunity, Autoimmunity and Alloreactive Immunity (III)

Aristo Vojdani and Jonathan Erde

Immunosciences Lab., Inc. 8693 Wilshire Boulevard, Suite 200, Beverly Hills, CA 90211, USA

Regulatory T (Treg) cells are the major arbiter of immune responses, mediating actions through the suppression of inflammatory and destructive immune reactions. Inappropriate Treg cell frequency or functionality potentiates the pathogenesis of myriad diseases with ranging magnitudes of severity. Lack of suppressive capability hinders restraint on immune responses involved in autoimmunity and alloreactivity, while excessive suppressive capacity effectively blocks processes necessary for tumor destruction. Although the etiology of dysfunctional Treg cell populations is under debate, the ramifications, and their mechanisms, are increasingly brought to light in the medical community. Methods that compensate for aberrant immune regulation may not address the underlying complications; however, they hold promise for the alleviation of debilitating immune system-related disorders. The dominant immunoregulatory nature of Treg cells, coupled with recent mechanistic knowledge of natural immunomodulatory compounds, highlights the importance of Treg cells to practitioners and researchers of complementary and alternative medicine (CAM).

Keywords: alloreactive immunity – autoimmunity – CAM – Cancer – regulatory T Cells – Treg

For reprints and all correspondence: Dr Aristo Vodjani, Immunosciences Lab., Inc., 8693 Wilshire Boulevard, Suite 200, Beverly Hills, CA 90211, USA. Tel: +1-310-657-1077; Fax: +1-310-657-1053; E-mail: immunsci{at}ix.netcom


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