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eCAM Advance Access originally published online on April 5, 2006
eCAM 2006 3(2):261-265; doi:10.1093/ecam/nel010
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© The Author (2006). Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Antimicrobial Activity of Indigofera suffruticosa

Sônia Pereira Leite1, Jeymesson Raphael Cardoso Vieira2, Paloma Lys de Medeiros1, Roberta Maria Pereira Leite3, Vera Lúcia de Menezes Lima4, Haroudo Satiro Xavier5 and Edeltrudes de Oliveira Lima6

1 Departamento de Histologia e Embriologia do Centro de Ciências Biológicas da Universidade Federal de Pernambuco Recife-PE, Brazil, 2 Mestrando em Patologia Geral do Centro de Ciências da Saúde da Universidade Federal de Pernambuco Recife-PE, Brazil, 3 Doutoranda em Nutrição do Centro de Ciências da Saúde da Universidade Federal de Pernambuco Recife-PE, Brazil, 4 Departamento de Bioquímica do Centro de Ciências Biológicas da Universidade Federal de Pernambuco Recife-PE, Brazil, 5 Departamento de Centro de Ciências Biológicas da Universidade Federal de Pernambuco Recife-PE, Brazil, and 6 Departamento de Ciências Farmacêutica do Centro de Ciências da Saúde da Universidade Federal da Paraíba João Pessoa-PB, Brazil

Various organic and aqueous extracts of leaves of Indigofera suffruticosa Mill (Fabaceae) obtained by infusion and maceration were screened for their antibacterial and antifungal activities. The extracts were tested against 5 different species of human pathogenic bacteria and 17 fungal strains by the agar-solid diffusion method. Most of the extracts were devoid of antifungal and antibacterial activities, except the aqueous extract of leaves of I. suffruticosa obtained by infusion, which showed strong inhibitory activity against the Gram-positive bacteria Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 5000 µg ml–1. The MIC values to dermatophyte strains were 2500 µg ml–1 against Trichophyton rubrum (LM-09, LM-13) and Microsporum canis. This study suggests that aqueous extracts of leaves of I. suffruticosa obtained by infusion can be used in the treatment of skin diseases caused by dermatophytes.

Keywords: antibacterial activity – antifungal activity – aqueous extract – Indigofera suffruticosa

For reprints and all correspondence: Sônia Pereira Leite, Laboratório de Cultura de Células II, Departamento de Histologia e Embriologia do Centro de Ciências Biológica da Universidade Federal de Pernambuco (UFPE). Cidade Universitária. Recife 50 670-420, Rua Alemanha 44 Apto 303 Imbiribeira Recife Pernambuco, Brazil. Tel: +55-81-21268515; Fax: +55-81-21268516; E-mail: spl{at}ufpe.br


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