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eCAM Advance Access originally published online on May 3, 2006
eCAM 2006 3(2):249-254; doi:10.1093/ecam/nel006
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© The Author (2006). Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Bioactive Constituents of Brazilian Red Propolis

Boryana Trusheva1, Milena Popova1, Vassya Bankova1, Svetlana Simova1, Maria Cristina Marcucci2, Patricia Laguna Miorin2, Flavia da Rocha Pasin2 and Iva Tsvetkova3

1 Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences 1113 Sofia, Bulgaria, 2 Faculdade de Farmacia, Universidade Bandeirante de Sao Paulo Rua Maria Candida, 1813, Vila Guilherme, Campus MC, 02071-013 Sao Paulo, SP Brazil, and 3 Institute of Microbiology, Bulgarian Academy of Sciences Acad. G. Bonchev Street, Building 26, 1113 Sofia, Bulgaria

In a new propolis type, red Brazilian propolis, 14 compounds were identified (six of them new for propolis), among them simple phenolics, triterepenoids, isoflavonoids, prenylated benzophenones and a naphthoquinone epoxide (isolated for the first time from a natural source). Three of the major components demonstrated significant antimicrobial activity, and two (obtained as inseparable mixture) possessed radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).

Keywords: antibacterial activity – chemical constituents – propolis – radical scavenging activity

For reprints and all correspondence: Vassya Bankova, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. Tel: +359-2-9606149; Fax: +359-2-8700225; E-mail: bankova{at}orgchm.bas.bg


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