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eCAM Advance Access originally published online on April 25, 2006
eCAM 2006 3(2):237-247; doi:10.1093/ecam/nel003
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© The Author (2006). Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Epicatechins Purified from Green Tea (Camellia sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines

Mepur H. Ravindranath1, Thiruverkadu S. Saravanan1, Clarence C. Monteclaro1, Naftali Presser1, Xing Ye1, Senthamil R. Selvan2 and Stanley Brosman3

1 Department of Glycoimmunotherapy, John Wayne Cancer Institute Santa Monica, CA, 2 Cell Biology Laboratory, Hoag Cancer Center, Hoag Memorial Hospital Presbyterian Newport Beach, CA, and 3 Pacific Clinical Research Santa Monica, CA

The anticancer potential of catechins derived from green tea is not well understood, in part because catechin-related growth suppression and/or apoptosis appears to vary with the type and stage of malignancy as well as with the type of catechin. This in vitro study examined the biological effects of epicatechin (EC), epigallocatechin (EGC), EC 3-gallate (ECG) and EGC 3-gallate (EGCG) in cell lines from human gender-specific cancers. Cell lines developed from organ-confined (HH870) and metastatic (DU145) prostate cancer, and from moderately (HH450) and poorly differentiated (HH639) epithelial ovarian cancer were grown with or without EC, EGC, ECG or EGCG. When untreated cells reached confluency, viability and doubling time were measured for treated and untreated cells. Whereas EC treatment reduced proliferation of HH639 cells by 50%, EGCG suppressed proliferation of all cell lines by 50%. ECG was even more potent: it inhibited DU145, HH870, HH450 and HH639 cells at concentrations of 24, 27, 29 and 30 µM, whereas EGCG inhibited DU145, HH870, HH450 and HH639 cells at concentrations 89, 45, 62 and 42 µM. When compared with EGCG, ECG more effectively suppresses the growth of prostate cancer and epithelial ovarian cancer cell lines derived from tumors of patients with different stages of disease.

Keywords: Green tea – epicatechin (EC) – epigallocatechin (EGC) – EC 3-gallate (ECG) – EGC 3-gallate (EGCG) – organ-confined – metastatic – prostate cancer – epithelial ovarian cancer – viability – doubling time – 50% inhibitory concentration (IC50)

For reprints and all correspondence: Mepur H. Ravindranath, Department of Glycoimmunotherapy, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404-2302, USA. Tel: +1-310-449-5263; Fax: +1-310-449-5259; E-mail: Ravindranathm{at}jwci.org


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