Skip Navigation


eCAM Advance Access originally published online on October 3, 2005
eCAM 2005 2(4):529-536; doi:10.1093/ecam/neh123
This Article
Right arrow Full Text Freely available
Right arrow Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
2/4/529    most recent
neh123v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Han, Y.
Right arrow Articles by Song, J.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Han, Y.
Right arrow Articles by Song, J.-Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Modulation of Radiation-Induced Disturbances of Antioxidant Defense Systems by Ginsan

Youngsoo Han1, Soo-Jung Son1, Medea Akhalaia1,3, Alexander Platonov1,3, Hyeog-Jin Son1, Kee-Ho Lee2, Yeon-Sook Yun1 and Jie-Young Song1,*

1Laboratory of Radiation Immunology, Korea Institute of Radiological and Medical Sciences 215-4 Gongneung-dong, Nowon-Ku, Seoul 139-706, Korea, 2Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences 215-4 Gongneung-dong, Nowon-Ku, Seoul 139-706, Korea, and 3Laboratory of Radiation Biophysics, Department of Biological Faculty, Moscow State University Vorobiovi gori, Moscow 119899, Russia

There are numerous studies to indicate that irradiation induces reactive oxygen species (ROS), which play an important causative role in radiation damage of the cell. We evaluated the effects of ginsan, a polysaccharide fraction extracted from Panax ginseng, on the {gamma}-radiation induced alterations of some antioxidant systems in the spleen of Balb/c mice. On the 5th day after sublethal whole-body irradiation, homogenized spleen tissues of the irradiated mice expressed only marginally increased mRNA levels of Mn-SOD (superoxide dimutase) in contrast to Cu/Zn-SOD, however, catalase mRNA was decreased by ~50% of the control. In vivo treatment of non-irradiated mice with ginsan (100 mg kg–1, intraperitoneal administration) had no significant effect, except for glutathione peroxidase (GPx) mRNA, which increased to 144% from the control. However, the combination of irradiation with ginsan effectively increased the SODs and GPx transcription as well as their protein expressions and enzyme activities. In addition, the expression of heme oxygenase-1 and non-protein thiol induced by irradiation was normalized by the treatment of ginsan. Evidence indicated that transforming growth factor-ß and other important cytokines such as IL-1, TNF and IFN-{gamma} might be involved in evoking the antioxidant enzymes. Therefore, we propose that the modulation of antioxidant enzymes by ginsan was partly responsible for protecting the animal from radiation, and could be applied as a therapeutic remedy for various ROS-related diseases.

Keywords: antioxidant enzyme – cytokine – ginsan – radiation

*For reprints and all correspondence: Jie-Young Song, Laboratory of Radiation Immunology, Korea Institute of Radiological and Medical Sciences, KAERI 215-4, Gongneung-dong, Nowon-ku, Seoul, 139-706, Korea. Tel: +82-2-970-1308; Fax: +82-2-977-0381; E-mail: immu{at}kcch.re.kr


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
T. Jahangir and S. Sultana
Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model
Evid. Based Complement. Altern. Med., December 1, 2007; 4(4): 439 - 445.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
R. Chawla, R. Arora, S. Singh, R.K. Sagar, R. K. Sharma, R. Kumar, A. Sharma, R. P. Tripathi, S. C. Puri, H. A. Khan, et al.
Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans
Evid. Based Complement. Altern. Med., December 1, 2006; 3(4): 503 - 511.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.