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eCAM Advance Access originally published online on November 8, 2005
eCAM 2005 2(4):503-512; doi:10.1093/ecam/neh127
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© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Review

Post-Traumatic Stress Disorder: Evidence-Based Research for the Third Millennium

Javier Iribarren3, Paolo Prolo1,2, Negoita Neagos2 and Francesco Chiappelli1,2,*

1UCLA School of Dentistry Los Angeles, CA, USA, 2Psychoneuroimmunology Group, Inc. Los Angeles, CA, USA, and 3David Geffen School of Medicine at UCLA Los Angeles, CA, USA

The stress that results from traumatic events precipitates a spectrum of psycho-emotional and physiopathological outcomes. Post-traumatic stress disorder (PTSD) is a psychiatric disorder that results from the experience or witnessing of traumatic or life-threatening events. PTSD has profound psychobiological correlates, which can impair the person's daily life and be life threatening. In light of current events (e.g. extended combat, terrorism, exposure to certain environmental toxins), a sharp rise in patients with PTSD diagnosis is expected in the next decade. PTSD is a serious public health concern, which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention. We review the current knowledge of PTSD and introduce the role of allostasis as a new perspective in fundamental PTSD research. We discuss the domain of evidence-based research in medicine, particularly in the context of complementary medical intervention for patients with PTSD. We present arguments in support of the notion that the future of clinical and translational research in PTSD lies in the systematic evaluation of the research evidence in treatment intervention in order to insure the most effective and efficacious treatment for the benefit of the patient.

Keywords: post-traumatic stress syndrome – allostasis – evidence-based research – complementary medicine

*For reprints and all correspondence: Francesco Chiappelli, UCLA School of Dentistry, CHS 63-090, Los Angeles, CA 90095-1668, USA. Tel: +1-310-794-6625; Fax: +1-310-794-7109; E-mail: chiappelli{at}dent.ucla.edu


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