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eCAM Advance Access originally published online on July 26, 2005
eCAM 2005 2(3):383-386; doi:10.1093/ecam/neh103
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© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Cisplatin Nephrotoxicity and Protection by Milk Thistle Extract in Rats

Gholamreza Karimi*, Mohammad Ramezani and Zahra Tahoonian

Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences Mashhad, Iran

The protective effect of methanolic extract of milk thistle seeds and silymarin against cisplatin-induced renal toxicity in male rats after a single intraperitoneal injection of 3 mg kg–1 cisplatin were studied. Over 5 days, cisplatin-treated rats showed tubular necrosis and elevation in blood urea nitrogen (BUN) and serum creatinine (Scr). Pretreatment of animals with silymarin (50 mg kg–1) or extract (0.6 g kg–1) 2 h before cisplatin prevented the tubular damage. Rats treated with silymarin or extract 2 h after cisplatin had BUN and Scr significantly lower than those receiving cisplatin, but mild to moderate necrosis was observed. These results suggested that milk thistle may protect against cisplatin-induced renal toxicity and might serve as a novel combination agent with cisplatin to limit renal injury.

Keywords: cisplatin – milk thistle – renal toxicity – silymarin

*For reprints and all correspondence: Dr Gholamreza Karimi, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Khorasan 91775-1365, Iran. Tel: 0511-8823255; Fax: 0511-8823251; E-mail: gho_karimi{at}yahoo.com


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