Skip Navigation


eCAM Advance Access originally published online on July 5, 2005
eCAM 2005 2(3):375-381; doi:10.1093/ecam/neh099
This Article
Right arrow Full Text Freely available
Right arrow Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
2/3/375    most recent
neh099v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Punitha, I. S. R.
Right arrow Articles by Shirwaikar, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Punitha, I. S. R.
Right arrow Articles by Shirwaikar, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Alcoholic Stem Extract of Coscinium fenestratum Regulates Carbohydrate Metabolism and Improves Antioxidant Status in Streptozotocin–Nicotinamide Induced Diabetic Rats

I. S. R. Punitha1, K. Rajendran1, Arun Shirwaikar2 and Annie Shirwaikar1,*

1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences Manipal 576104, India, and 2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences Manipal 576104, India

Alcoholic extract of the stems of Coscinium fenestratum, a medicinal plant indigenous to India and Sri Lanka used in ayurveda and siddha medicine for treating diabetes, was studied for its carbohydrate metabolism effect and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetic rats. Oral administration of C. fenestratum stem extract in graded doses caused a significant increase in enzymatic antioxidants such as catalase, superoxide dismutase, glutathione synthetase, peroxidase, and glutathione peroxidase and in the nonenzymatic antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of alcoholic extract on glycolytic enzymes such as glucose-6-phosphate dehydrogenase, lactate dehydrogenase and hexokinase showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme, glucose-6-phosphatase and alanine aminotransferase in treated diabetic rats. Serum creatinine and urea levels also declined significantly. This investigation demonstrates significant antidiabetic activity of C. fenestratum.

Keywords: carbohydrate metabolism – Coscinium fenestratum – enzymatic antioxidants – nonenzymatic antioxidants – streptozotocin–nicotinamide induced diabetes

*For reprints and all correspondence: Dr Annie Shirwaikar, Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka 576104, India. Tel: 191 820 2571201 22430; Fax: 191 820 2571998; E-mail: annieshirwaikar{at}yahoo.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
N. P. Visavadiya and A. V. R. L. Narasimhacharya
Asparagus Root Regulates Cholesterol Metabolism and Improves Antioxidant Status in Hypercholesteremic Rats
Evid. Based Complement. Altern. Med., June 1, 2009; 6(2): 219 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
S. A. Adesegun, A. Fajana, C. I. Orabueze, and H. A. B. Coker
Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae)
Evid. Based Complement. Altern. Med., June 1, 2009; 6(2): 227 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
M. Bhat, S. K. Kothiwale, A. R. Tirmale, S. Y. Bhargava, and B. N. Joshi
Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis: In Vivo Studies in Murine Diabetes Model
Evid. Based Complement. Altern. Med., April 23, 2009; (2009) nep033v1.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
S. K. Singh, P. K. Rai, D. Jaiswal, and G. Watal
Evidence-based Critical Evaluation of Glycemic Potential of Cynodon dactylon
Evid. Based Complement. Altern. Med., December 1, 2008; 5(4): 415 - 420.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
G. Klein, J. Kim, K. Himmeldirk, Y. Cao, and X. Chen
Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa
Evid. Based Complement. Altern. Med., December 1, 2007; 4(4): 401 - 407.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
M. M. Essa and P. Subramanian
Hibiscus sabdariffa Affects Ammonium Chloride-Induced Hyperammonemic Rats
Evid. Based Complement. Altern. Med., September 1, 2007; 4(3): 321 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
R. Xia, P. Huang, and G.-m. Shao
Nourishing Yin and Promoting Blood Circulation of TCM to Treat Hemorheologic Disorder Induced by Diabetes Mellitus in Rats
Evid. Based Complement. Altern. Med., June 1, 2007; 4(2): 203 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
S. Salvioli, E. Sikora, E. L. Cooper, and C. Franceschi
Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies
Evid. Based Complement. Altern. Med., June 1, 2007; 4(2): 181 - 190.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
J. Z. Luo and L. Luo
American Ginseng Stimulates Insulin Production and Prevents Apoptosis through Regulation of Uncoupling Protein-2 in Cultured {beta} Cells
Evid. Based Complement. Altern. Med., September 1, 2006; 3(3): 365 - 372.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.