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eCAM Advance Access originally published online on April 20, 2005
eCAM 2005 2(2):223-226; doi:10.1093/ecam/neh086
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© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Brief Communication

Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)

Sachiko Tsukamoto, Maki Aburatani and Tomihisa Ohta*

Graduate School of Natural Science and Technology, Kanazawa University Kakuma-machi, Kanazawa 920-1192, Japan

Recent investigation on drug interaction has shown that some foods and herbal medicines increase the oral availability of a variety of CYP3A4 substrates, which is caused by the reduction of CYP3A4 in intestinal epithelium. During the course of our investigation on CYP3A4 interaction, we found that the commercially available dietary supplement made from black cohosh (Cimicifuga racemosa) showed CYP3A4 inhibition. Black cohosh has been used for the treatment of menopausal and post-menopausal symptoms as a dietary supplement. Bioassay-guided isolation from the supplement afforded six active principles, which were identified as cycloartanoid triterpene glycosides.

Keywords: black cohosh – Cimicifuga racemosa – CYP3A4 – cytochrome P450 – inhibition – triterpene glycoside

*For reprints and all correspondence: Tomihisa Ohta, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192 Japan. Tel: +81-76-234-4468; Fax: +81-76-264-6241; E-mail: ohta{at}p.kanazawa-u.ac.jp


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No characterisation of the extract and questionable in-vivo correlation.
Beat Meier, et al.
Evidence-based Complementary and Alternative Medicine, 12 Aug 2005 [Full text]

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